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- Kliovance
Kliovance
Buy Kliovance after completing our online consultation for menopause symptoms
Prices include next-day delivery and prescription
| 3 months £29.99 | 84 tablets |
| 6 months £54.99 | 168 tablets |
Select your treatment after the consultation:
Benefits of product
Gentle, steady menopause relief in a single daily tablet
- Lower-dose continuous HRT - designed for steady, everyday comfort
- No monthly bleeds, making it a convenient option for post-menopausal women
- Easy daily use with a rotating calendar dispenser
- Ideal for women sensitive to higher doses or starting combined HRT for the first time
Kliovance vs Kliofem
Kliovance and Kliofem are both continuous combined HRT tablets manufactured by Novo Nordisk. They contain oestrogen and progestogen in one daily pill. The main difference between them is the dose. See the comparison for a full summary.
 Kliovance |
 Kliofem |
|
|---|---|---|
| Format | Continuous combined tablet | Continuous combined tablet |
| Who it’s for | Women wanting a lower-dose continuous option | Women needing a standard/higher dose for stronger symptom control |
| Typical use | Mild-moderate symptoms, women who may benefit from a lower-dose continuous option | Moderate–severe symptoms requiring more support |
| Oestrogen dose | 1 mg estradiol | 2 mg estradiol |
| Progestogen dose | 0.5 mg norethisterone | 1 mg norethisterone |
| How to take | One tablet daily | One tablet daily |
| Presentation | Calendar pack | Calendar pack |
| Manufacturer | Novo Nordisk | Novo Nordisk |
How to use Kliovance
Take one tablet daily
A simple once-daily routine helps keep your hormones steady and easier to manage.
Use the daily calendar pack
Use the calendar pack device to help you remember to take your pills each day.
Start a new pack after the last
There are no breaks between packs. Continuous use maintains steady hormone levels.
Key facts
| Type of medicine | HRT (hormone replacement therapy) |
| Used for | Menopausal symptoms |
| Active ingredient | Estradiol with norethisterone |
| Works by | Supplementing oestrogen to help relieve menopause symptoms and providing progestogen to protect the womb lining. |
| Effective within | A few weeks to 3 months |
| Available as | Tablets |
| Available dosage(s) | 1mg of estradiol/ 0.5mg of norethisterone |
| Usage instructions | 1 tablet daily |
| Packaging | Film-coated tablets in a 28-day calendar pack |
| Manufacturer | Novo Nordisk |
| Generic available? | No |
| Storage | Do not store above 25 °C |
Excellent
4.8
76 patients have reviewed Kliovance on Trustpilot
Louise C , 19 Sep
No side effects releases menopausal symptoms
Linda L , 05 Apr
It works for me
Ally M , 09 Dec
Easy to take, no side effects
Louise C , 01 Dec
This is effective in relieving menopausal symptoms with no side effects
Louise C , 12 Sep
This is very effective in managing my menopausal symptoms and I would struggle without this medication
Samantha S , 11 Apr
This product makes my life so much easier to cope with.
Elaine , 25 Jan
Helps with my menopausal symptoms
Elaine , 25 Apr
Medication relied on for quality of life
Gail C , 18 Feb
Extremely good medication
More information about Kliovance
About Kliovance
What is Kliovance?
Kliovance is a continuous combined HRT tablet manufactured by Novo Nordisk. It is used to treat menopause symptoms such as hot flushes and night sweats.It contains both oestrogen and progestogen, meaning it is suitable for women with a womb
How does Kliovance work?
Kliovance contains two types of female hormones: oestrogen and progestogen. During the menopause, the amount of oestrogen in a woman’s body drops. This is what causes symptoms. Kliovance therefore supplements oestrogen levels to help treat these symptoms. The progestogen helps to protect the womb lining.
What are the benefits of Kliovance?
There are several benefits of using Kliovance. In addition to reducing the severity of menopause symptoms, it also offers several unique benefits.
- Bone health - it helps to maintain bone health, which helps reduce the risk of osteoporosis (a condition that causes weak bones).
- Womb protection - it contains a progestogen, which helps to protect the womb lining, reducing the risk of endometrial hyperplasia, which can lead to womb cancer.
- Convenience - Kliovance is available as a calendar pack, a little device that helps you remember to take your tablets each day.
Using Kliovance
What dose do I take?
Kliovance tablets contain 1 mg of estradiol and 0.5 mg of norethisterone. You take one tablet each day at roughly the same time.
How do I take Kliovance?
Kliovance is available as calendar packs. These are specialised disk-shaped devices organised by day of the week to help you remember to take them daily.
How to use the Kliovance calendar pack:
- Set the day reminder by turning the inner disc to set the day of the week opposite the little plastic tab.
- Take the first day’s tablet by breaking the plastic tab and tipping out the first tablet.
- The next day, move the dial clockwise 1 space as indicated by the arrow. This releases the next tablet. Tip it out.
- You move the dial every day. You can only turn the dial once the tablet has been removed.
Ask your doctor or pharmacist to show you how to use it if you are not sure.
What happens if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is more than 12 hours late, however, skip the missed dose and take the next tablet at the regularly scheduled time.
Safety and precautions
Who cannot use Kliovance?
Kliovance is safe for most women to relieve menopause symptoms.
Do not take Kliovance if you:
- are allergic to estradiol, norethisterone or any of the other ingredients
- have ever had breast cancer
- have a cancer which is sensitive to oestrogen, such as endometrial cancer (cancer of the womb)
- have any unexplained vaginal bleeding
- have excessive thickening of the womb lining (endometrial hyperplasia)
- have ever had a blood clot, such as in the legs or the lungs
- have a blood-clotting disorder
- have had a heart attack, stroke or angina (conditions caused by blood clotting)
- have a liver disease
- have a blood condition called porphyria
What are the most common side effects of Kliovance?
Common side effects of Kliovance include:
- headache
- migraine (new or worse than before)
- stomach pain
- back pain
- tender or painful breasts
- vaginal thrush (a fungal infection)
- feeling anxious, depressed or nervous
- feeling sick or vomiting
- irregular, light, heavy or painful periods
- weight gain
- swelling of the ankles, feet or fingers
- vaginal discharge
This is not a full list of side effects. Please refer to the complete list of side effects in the patient information leaflet (PIL).
How safe is Kliovance?
Since its approval in the UK in March 1998, Kliovance has been considered safe for most women, provided it’s prescribed by a licensed healthcare professional.
However, as with all HRT medicines, it can pose some risk. You should take special care if you have a condition that makes you more likely to get a blood clot. Speak with your doctor if you’re unsure about the safety of treatment with Kliovance.
