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Lenzetto Spray

Buy Lenzetto Spray after completing our online consultation for menopause symptoms

1.53mg
3 months 2 packs x 56 sprays (£39.99)

Prices include next-day delivery and prescription

3 months £39.99 2 packs x 56 sprays
6 months £59.99 4 packs x 56 sprays

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An overview

Benefits of product

Woman using a spray on her forearm.

Simple, quick-drying oestrogen spray for steady relief

  • Quick-drying daily spray for simple, fuss-free use
  • Discreet and lightweight - no patches or tablets
  • Adjustable dosing to match your symptoms and needs
  • Provides steady oestrogen support to relieve menopause symptoms
The facts

Lenzetto vs Oestrogel

Lenzetto and Oestrogel are both equally effective forms of topical HRT. But they each have unique benefits. See the comparison below.

Lenzetto Spray Oestrogel
Format Transdermal spray Transdermal gel
Instructions Apply 1 spray to the inner forearm once a day Apply 2 pumps of gel to the inner arm once a day
Texture & absorption Thin colourless solution, dries in 2 minutes Clear gel, dries in 5 minutes
Application No rubbing in - minimal contact transfer risks Requires spreading over the skin
Dose measurement Single spray bottle with measured sprays Single bottle with measured pumps
Packaging Small, discreet spray bottle Larger pump bottle
Who it may suit Women who prefer a quick application and a thin solution Women who prefer a thicker gel that they can spread
Practical info

How to use Lenzetto Spray

A close-up of a woman’s arms.

Apply to clean, dry skin

Use the spray on the inner forearm, ensuring the skin is clean and free from creams.

Woman using Lenzetto spray on forearm.

Press the spray once per dose

Hold the bottle upright, press firmly, and let the spray settle on the skin.

A white analogue clock.

Allow to dry fully

Let the spray dry completely and avoid touching or covering the area for 2 minutes.

Quick overview

Key facts

Type of medicine HRT (hormone replacement therapy)
Used for Menopausal symptoms
Active ingredient Estradiol
Works by Supplementing oestrogen to help relieve menopause symptoms.
Effective within 3 months
Available as Transdermal spray
Available dosage(s) 1.53 mg estradiol per spray
Usage instructions Apply 1 spray daily to the inner forearm
Packaging Cardboard carton containing a plastic container with a 6.5 ml glass container inside
Manufacturer Gedeon Richter
Generic available? No
Storage Do not store above 25°C
Independently collected reviews Service reviews
Excellent 4.7 26,973 patients have reviewed our service on Trustpilot
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Stuart D , 22 Apr

product as described, good price and promptly dispatched.

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Mr Parker , 22 Apr

My original card was compromised. My new card number was accepted without problems. I then received my medication promptly.

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David K , 21 Apr

next day delivery always arrives on time

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Jennifer A , 21 Apr

Always fast and reliable service

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Richard F , 20 Apr

Good selection of products to choose from after the consultation period, the questions do seem thorough to reach a conclusion. Th product I chose was delivered fast and with fantastic communication, I wouldn’t hesitate to recommend these people. Thank you to all .

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Febiola L , 20 Apr

Easy to order and smooth delivery throughout.

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Sally C , 20 Apr

Easy to order Quick delivery

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Mrs fredericks , 20 Apr

Order arrived late. Ice pack had completely melted.

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Mark , 20 Apr

I had a lot of trouble with reordering from the website. At the final stage the site was endlessly buffering. I accessed my account again from a different web browser and the same thing happened. The online chat wasn’t much help, advising me to delete my history and try again - no joy. Then I was asked to call the helpline. When I did this I was informed there was no one available and asked to leave a message, which I did. No one called back. It was only on the second occasion that I got through to a person who confirmed my order. In the days following I was bombarded by electronic emails telling me I had an incomplete order (which I didn’t) and asking if a needed help (!)

Your questions answered

More information about Lenzetto Spray

About Lenzetto Spray

What is Lenzetto spray?

Lenzetto spray is a topical hormone replacement therapy (HRT) manufactured by Gedeon Richter. It helps to improve menopausal symptoms such as hot flushes and night sweats by helping to balance your hormone levels.

How does Lenzetto spray work?

Lenzetto spray contains estradiol, which is a synthetic form of the reproductive hormone oestrogen. During menopause, oestrogen levels fall, which is what causes symptoms. Lenzetto therefore works by restoring your oestrogen levels, reducing these symptoms.

What are the benefits of Lenzetto spray?

As well as reducing menopause symptoms, Lenzetto has several unique benefits:

  • Fewer side effects compared to oral HRT - the medicine is absorbed into the skin, bypassing the liver, which can help reduce the risk of serious side effects.
  • Easy to apply - you spray a solution once on your inner arm, no need to rub it in, and no further action needed.
  • Non-greasy - the solution is discreet and colourless, with no residue once dry.
  • Good for sensitive skin - no patch adhesive, useful for women who react to patches.

Does Lenzetto contain progesterone?

No, Lenzetto only contains oestrogen. You will need to take a progestogen if you have a womb to stop the lining of the womb from thickening too much. This helps to reduce the risk of cancer of the womb (endometrial cancer).

Using Lenzetto Spray

What dose do I use?

Always follow the instructions from your doctor or specialist. The usual dose is 1 spray once a day. Your doctor may increase this to 2-3 sprays once a day if needed.

How do I apply Lenzetto Spray?

You apply each spray to your inner forearm on healthy, clean skin. Do not spray near your breasts or on any broken skin.

  1. When using it for the first time, prepare the spray by spraying it 3 times with the plastic cover on.
  2. When you’re ready, take the plastic cover off and hold the container upright.
  3. Rest the plastic cone on our inner arm flat against the skin.
  4. Press the button down fully and hold it down to release a dose.
  5. If you need to apply another spray, move the cone down along your arm and repeat steps 2-3.
  6. You may also spray on your other arm or inner thigh if you are having trouble fitting the doses on your arm.
  7. Let the spray dry for 2 minutes before dressing, and wait 60 minutes before bathing.
  8. Do not massage or rub the solution into the skin.

Sun cream can interact with Lenzetto. If you need to apply sun cream, apply it at least 1 hour before applying Lenzetto.

What happens if I forget to use it?

Spray Lenzetto as soon as you remember and then apply your next dose as usual. If you have forgotten it and it is nearly time for your next dose, wait and apply the next dose at the usual time. Missing doses may increase the risk of breakthrough bleeding and spotting.

Safety and precautions

Who cannot use Lenzetto Spray?

Do not use Lenzetto spray if you have:

  • ever had breast cancer
  • a cancer which is sensitive to oestrogen, such as endometrial cancer (cancer of the womb)
  • any unexplained vaginal bleeding
  • a blood-clotting disorder
  • had a heart attack, stroke or angina (conditions caused by blood clotting)
  • a liver disease or irregular liver function test results
  • an inherited blood condition called porphyria

What are the most common side effects of Lenzetto Spray?

Common side effects of Lenzetto include:

  • headache
  • stomach pain
  • nausea
  • rash
  • itching
  • irregular vaginal bleeding
  • breast pain
  • weight loss or gain

This is not a full list of side effects. Please refer to the patient information leaflet for a complete list of side effects.

How safe is Lenzetto Spray?

Lenzetto is considered safe, provided you get a prescription from a licensed healthcare professional. It was approved for use in the UK in April 2020, and since then has been a trusted product for many who rely on it for effective HRT treatment.

However, as with all HRT medicines, it can pose some risk. You should take special care if you have a condition that makes you more likely to get a blood clot. Speak with your doctor if you’re unsure about the safety of treatment with Lenzetto.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 01-04-2026
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