Foundayo is a weight management pill that reduces your appetite and slows digestion to help you eat less. When taken daily alongside a healthy diet and regular exercise, it helps you lose weight safely and effectively.
Foundayo contains the active ingredient orforglipron. It helps you lose weight by regulating appetite, slowing stomach emptying, and lowering blood sugar levels so you eat less.
Unlike older GLP-1s like Mounjaro and Wegovy, Foundayo is not destroyed by stomach acid. That means you can take it orally in tablet form without the need to fast beforehand. This makes it a convenient and simple way to support weight loss.
Foundayo comes in the form of a daily tablet, meaning you do not need to inject yourself and can easily fit it into your daily routine.
A Foundayo clinical trial found that you can lose up to 12.4% of your body weight in 72 weeks.2
| Foundayo pills (17.2 mg) | Wegovy pills (25 mg) | |
|---|---|---|
| Avg. weight loss2 3 | Up to 12.4% | Up to 17% |
| Active ingredient | Orforglipron | Semaglutide |
| Schedule | Daily tablet | Daily tablet |
| Dose flexibility | Increase, decrease or maintain monthly | Increase, decrease or maintain monthly |
| Fasting required? | No, can be taken with or without food | Yes, for at least 8 hours beforehand |
| Needles required? | No | No |
| After taking it | No waiting before drinking or eating | Wait 30 minutes before drinking or eating |
| Cost | - | £119.00 |
Choose a time of day to take your tablets that suits you. You can take it at any time of the day as long as you stick to it.
Take your tablet at the chosen time. You do not need to take it with food or water, but this may help ease side effects.
Take your tablets at the same time every day for long-term weight management.
Foundayo is taken once per day, starting at the lowest dose of 0.8 mg for at least 30 days.
Your dose can then be increased by one step each month, up to the maximum dose of 17.2 mg. Gradually increasing the dose gives your body time to adjust and helps reduce the risk of side effects.
Keep in mind that you do not have to increase your dose if you are comfortable on a lower one, but doing so can improve results.
Dosage chart
Follow the step-up schedule below to optimize your treatment plan.
1st day
Congrats on starting your weight loss journey with Foundayo!
1-2 weeks
You’re settling into your new routine.
1 month
You’ve now completed your first month of treatment.
3 months
You’re settling into your new routine.
6 months+
Continue progressing for long-term weight management.
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| Type of medicine | GLP-1 receptor agonist |
| Used for | Obesity and weight loss |
| Active ingredient | Orforglipron |
| Works by | Mimicking a hormone that regulates blood sugar and appetite |
| Effective within | 4 weeks |
| Available as | Tablets |
| Available dosage(s) | 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, 17.2 mg |
| Usage instructions | Take one pill daily with or without food |
| Packaging | A pack containing 30 film-coated tablets |
| Manufacturer | Eli Lilly |
| Generic available? | No |
| Storage | Store in the original packaging to protect from light. |
Yes, Foundayo was approved for weight management by the MHRA on 10 August 2026.4
That means it is available to purchase from a licensed healthcare provider like HealthExpress following a successful online consultation.
No, Foundayo is not the same as Mounjaro, but they do share some similarities. Most notably, both are weight loss treatments known as GLP-1s, and both are manufactured by Eli Lilly.
However, Mounjaro is a weekly injection, whereas Foundayo is a daily tablet. They also contain different active ingredients.
Foundayo is a once-daily oral GLP-1 treatment that can be taken at any time of day, with or without food and without specific food or water restrictions. This makes it a convenient alternative for people who prefer tablets or don't want to follow the administration requirements of other oral GLP-1 treatments.
Yes, it is typically safe to switch from a GLP-1 injection to Foundayo, and this can be particularly beneficial to people who prefer tablets to injections.
If you are already on a higher dose of a GLP-1 like Mounjaro or Wegovy, you may be able to switch to an equivalent dose of Foundayo. One of our doctors can instruct you on this after your consultation.
To find out if you’re eligible for weight loss treatment, start a consultation with HealthExpress and our doctors can recommend the best treatment for your needs.
No. Unlike some other oral GLP-1 treatments, Foundayo can be taken with or without food or water, so you don’t need to fast before taking your tablets.
If it’s the same day, take the missed dose as soon as you remember. If it has been more then 24 hours, then skip the missed dose and take your next one at the usual time.
Do not take more than one tablet in one day.
The most common side effects of Foundayo are gastrointestinal, including nausea, diarrhoea, vomiting, constipation, stomach pain, headache, fatigue, and heartburn. This is because it works mainly in your gut.
However, not everyone will experience side effects, and most should go away after the first few weeks as your body gets used to the medicine.
Yes. Foundayo is designed to be used alongside a reduced-calorie diet and increased physical activity. Choosing nutritious, filling foods can help support your weight-loss goals.
For more information, you can read our article on how many calories you should eat per day.
Yes. Foundayo is prescribed alongside a reduced-calorie diet and increased physical activity as part of a complete weight-loss programme. Regular exercise can support your weight-loss progress, help maintain muscle and improve your overall health while taking Foundayo.
For more information, you can read our dedicated article on the importance of exercise for weight loss.
Staying well hydrated is essential when taking Foundayo, especially if you experience side effects that cause dehydration, like nausea, vomiting or diarrhoea.
It’s also important for overall health and, according to research, it can potentially help with weight loss.5
Resources
*1 Foundayo: https://foundayo.lilly.com/what-is-foundayo
*2 Foundayo clinical trial: https://www.nejm.org/doi/10.1056/NEJMoa2511774
*3 Wegovy pill clinical trial: https://www.nejm.org/doi/full/10.1056/NEJMoa2500969
*4 Foundayo UK approval: https://www.gov.uk/government/news/uk-first-in-europe-to-authorise-orforglipron-for-weight-management-and-type-2-diabetes.
*5 Hydration and weight loss: https://pmc.ncbi.nlm.nih.gov/articles/PMC4901052/