Evorel Sequi

Evorel Sequi is a sequential hormone replacement therapy (HRT) with two different patches: one containing oestrogen only, and the other containing a combination of oestrogen and progestogen. When applied twice weekly, they release hormones through the skin to help ease symptoms of menopause like night sweats, hot flushes, and sleep disruption.

After a short online consultation, a HealthExpress menopause specialist can assess whether Evorel Sequi or another Evorel patch is the most suitable option for you.

Evorel Sequi contains two different patches for two phases of your treatment cycle. The first patch contains estradiol only, and manages menopausal symptoms. The second patch contains both estradiol and norethisterone, helping to maintain balanced hormone levels while protecting your uterus. Here’s how each ingredient works:

• Estradiol: body-identical form of oestrogen that rebalances hormone levels to ease symptoms of menopause.
• Norethisterone: A type of progestogen that protects your womb lining from excessive thickening.

This dual-action formula ensures effective symptom control while protecting your uterus, and is primarily prescribed to perimenopausal women.

Using Evorel Sequi for menopause offers many health benefits:

• Eases menopause symptoms: including night sweats, hot flushes, sleep disruptions, mood changes, nausea and more.
• Tailored for perimenopausal women: Evorel Sequi helps balance hormones during the perimenopausal phase, providing symptom relief while maintaining a monthly bleed.
• Safe for women with a womb: combined hormone formulation treats symptoms while protecting the uterus.
• Patches offer a lower risk of blood clots: Evorel Sequi patches carry a lower risk of blood clotting than oral HRTs, although the risk is not zero.
• Non-invasive HRT option: easy-to-apply patches allow for effective symptom control without the need to take daily tablets.
• Supports natural hormonal rhythm: The sequential approach follows a hormone pattern closer to a natural menstrual cycle, which may suit women who prefer a monthly bleed.

Follow these instructions when applying Evorel patches:

1. Choose a clean, dry, and hairless area of skin on the thighs or buttocks.
2. Apply 1 patch to the skin, ensuring there are no creases.
3. Change your patch on the same 2 days each week, leaving each one on for 3 or 4 days. 2 patches should last 7 days.
4. For the first 2 weeks, apply Evorel 50 patches. For the next 2 weeks, apply Evorel Conti patches.
5. Continue this cycle.

When you start using Evorel Sequi depends on a few factors. Follow this helpful guide to ensure you start treatment the right way.

Evorel 50 patches begin supplying oestrogen to the body as soon as a patch is applied, while Evorel Conti works to continue this support while protecting the uterus after the first 2 weeks. Following this schedule, it can take up to 3 weeks before a significant improvement in symptoms is noticed, and the full effects of Evorel Sequi should be felt after around 3 months of consistent use.

Evorel Sequi contains two doses of HRT patch used sequentially to manage symptoms of perimenopause while allowing for a monthly bleed. In each pack, there are:

• 4 Evorel 50 patches: these contain 50 mcg of estradiol, a type of oestrogen. They are to be applied twice-weekly for the first 2 weeks.
• 4 Evorel Conti patches: these contain 50 mcg of estradiol and 170 mcg of norethisterone, a type of progestogen.

This sequential approach to HRT is designed to mimic the natural menstrual cycle, so you treat symptoms effectively without changing your habits.

Evorel Sequi patches are usually prescribed for perimenopausal women who still have a womb and are experiencing menopausal symptoms. If you’ve had a hysterectomy (no womb), a different type of Evorel patch may be recommended. Our menopause specialists will help you choose the option that’s safest and most suitable for you.

Do not use Evorel Sequi if you have:

• an allergy to any ingredient found in this medicine
• ever had breast cancer or a cancer sensitive to oestrogens
• unexplained vaginal bleeding
• excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated
• ever had a blood clot in a vein or a blood clotting disorder
• recently had a disease caused by blood clots in the arteries, such as heart attack or stroke
• ever had a liver disease and your liver function tests have not returned to normal
• porphyria (a rare inherited blood disorder)

Like with all HRT, Evorel Sequi can cause some side effects, although not everyone will get them.

The most common Evorel Sequi side effects include:

• skin irritation where the patch is applied
• feeling depressed or nervous
• mood swings
• trouble sleeping
• headache
• itchy skin or a red rash
• nausea
• diarrhoea
• back, joint, or muscle pain
• breast pain
• feeling unwell
• weight gain
• heavy vaginal bleeding
• painful periods
• water retention

This is not an exhaustive list. For a full list of Evorel Conti side effects, consult the patient information leaflet

Evorel Sequi has been widely prescribed in the UK for many years and is considered safe for many women when used as directed and under the guidance of a licensed healthcare professional, such as a HealthExpress menopause specialist.