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- Menopause
- Estriol Cream (Gynest)
Estriol Cream
Buy Estriol cream after completing our online consultation for menopause
Prices include next-day delivery and prescription
| 1 tube £59.99 | 80g |
Select your treatment after the consultation:
Benefits of product
Local relief for intimate menopause symptoms
- Oestrogen HRT cream
- Designed for local relief from vaginal dryness, itching and discomfort
- Acts where it's needed, minimal absorption into the bloodstream
- Well-tolerated by most women
- Easy to apply with applicators
- Can be taken with oral HRT
How to use Estriol Cream
Apply once a day
You should apply Estriol once per day at night for 3-4 weeks. Then reduce the dose to twice a week.
Easy-to-use applicator
Fill the plastic applicator for each dose and insert it into the vagina.
Combine with other HRT
You can take other forms of HRT with Estriol to relieve other menopause symptoms such as hot flushes
Key facts
| Type of medicine | Hormone replacement therapy (HRT) |
| Used for | Vaginal dryness, soreness and itching linked to menopause |
| Active ingredient | Estriol |
| Works by | Replacing low oestrogen levels in the vagina to improve moisture and elasticity |
| Effective within | 3-4 weeks |
| Available as | Intravaginal cream |
| Available dosage(s) | 1 mg/g Estriol |
| Usage instructions | Apply one full applicator into the vagina once a day for 3-4 weeks |
| Packaging | 15 g tube of cream and plastic applicator in a cardboard carton |
| Manufacturer | Aspen Pharma |
| Generic available? | No |
| Storage | Do not store above 25°C |
Excellent
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27,043 patients have reviewed our service on Trustpilot
Jools P , 05 May
Very good. Do ask relevant questions but that's to be expected. Thank you. Always promp delivery x
John , 05 May
Delivered in timeframe
Jennie M , 04 May
The item was delivered incredibly quickly and arrived in good condition.
Paul L , 04 May
Excellent communication & fast delivery
John A , 04 May
Fast, reliable, accurate delivery timetable, no fuss.
Barry T , 04 May
Very good service and prompt deliveries
Gemma S , 03 May
Very professional and quick delivery
Michelle W , 03 May
Very good service. Product was delivered on time as arranged.
Sue J , 03 May
Dealt with my enquiry promptly and answered all my questions with clarity so I fully understood the prescription I was getting. Prompt delivery exactly as outlined and lots of information to ensure I was fully informed.
More information about Estriol Cream (Gynest)
About Estriol
What is Estriol cream?
Estriol cream is a topical hormone replacement therapy (HRT) for postmenopausal women. It is available in the form of a vaginal cream that you apply into the vagina using a plastic applicator. It is designed to relieve menopause symptoms such as vaginal dryness, itching, soreness and discomfort.
How does Estriol work?
Estriol is a form of the female hormone oestrogen. After menopause, oestrogen levels drop and can cause vaginal atrophy, a condition in postmenopausal women where the vaginal walls thin due to a lack of oestrogen. Estriol works by restoring oestrogen levels locally in the vaginal tissues, helping to relieve these symptoms.
What are the benefits of Estriol?
The main benefit of Estriol is its localised effect. It provides direct relief for vaginal dryness, which can help improve discomfort, painful sex, urinary issues and your overall quality of life.
The topical application means very little of the medicine is absorbed into the bloodstream, which helps reduce the risk of side effects compared with oral HRT.
Another benefit of Estriol is that it can be combined with other forms of HRT, such as patches or pills. This means you can target other menopause symptoms, such as hot flushes.
Is Estriol the same as Ovestin?
Ovestin is the branded version of the generic Estriol. They contain the same active ingredient, Estriol, and therefore work similarly. The only difference is the manufacturer and the price.
Using Estriol
What dose do I apply?
Estriol is applied using a plastic applicator. One full applicator delivers 0.5 g of cream, which contains 50 mcg of estriol. Apply one full applicator once daily for 3-4 weeks. You can then reduce the dose to one full applicator twice weekly.
Always follow the instructions from your doctor or our menopause specialists.
How do I apply Estriol?
You apply Estriol using a plastic applicator. You use the same applicator for each dose. You should apply Estriol at night to promote absorption and to reduce any leakage or discomfort during the day.
Instructions for applying Estriol:
- Remove the cap from the tube of cream and turn the cap upside down. Hold the sharp end of the tube.
- Screw the end of the applicator onto the tube.
- Squeeze the tube to fill the applicator with the cream up to the red ring mark (the plunger will stop at the red ring mark).
- Unscrew the applicator from the tube and put the cap back on the tube.
- To apply the cream, lie down and put the end of the applicator deep into your vagina.
- Then, slowly push the plunger all the way in.
- Once the plunger is all the way down, gently remove the applicator from your vagina.
After each use, you must clean the applicator. Make sure you remove the plunger from the barrel and wash both by hand with hot, soapy water. Do not use detergent or boiling water.
What happens if I miss a dose?
Apply the missed dose as soon as you remember, unless it is close to your next scheduled dose. In that case, skip the missed dose and continue as normal.
How long does it take for Estriol to work?
Your symptoms should improve within 3-4 weeks of consistent use. If your symptoms have not improved, please consult your doctor.
Safety & Precautions
Who can use Estriol?
Estriol is suitable for most women experiencing vaginal menopause symptoms.
However, Estriol may not be suitable for some women, particularly those with certain medical conditions. Your doctor will assess whether it is appropriate for you.
This includes women who have:
- ever had breast cancer or a cancer that is sensitive to oestrogen (e.g. cancer of the womb)
- unexplained vaginal bleeding
- untreated excessive thickening of the womb lining (endometrial hyperplasia)
- ever had a blood clot in the vein, legs or lungs
- ever had a disease caused by blood clotting (e.g. heart attack, stroke or angina)
- a blood-clotting disorder
- ever had a liver disease or abnormal liver function tests
- an allergy to estriol or any of the other ingredients in this medicine
If you have another medical condition that is not listed, take other medication or are due to have surgery, consult with your doctor before using Estriol. Our consultation service will also allow our doctors to ensure it’s safe for you to take.
What are the side effects of Estriol?
Like all prescription medicines, Estriol may cause some side effects. The most common side effects are mild and should subside on their own.
Common side effects include:
- pain when urinating
- changes in the vulva or vagina
- skin reactions
- vaginal discharge
Serious side effects are very rare with low-dose vaginal estriol. However, if you experience symptoms such as sudden severe headaches, signs of a blood clot or jaundice (yellowing of the skin or eyes), seek urgent medical advice.
For a full list of side effects, please refer to the patient information leaflet .
Does Estriol cause thrush?
Yes, Estriol can sometimes cause vaginal thrush. This is because elevated oestrogen levels can promote an overgrowth of Candida fungus. Thrush is a mild condition that often goes away on its own or with a short course of antifungal treatments like fluconazole .
Speak to a doctor or pharmacist if symptoms persist.
Is Estriol cream safe?
Yes, evidence shows that low-dose vaginal estriol is safe and effective for most women for relief of menopausal vaginal dryness.
Before starting treatment, you’ll complete a short online consultation with HealthExpress, where our menopause specialists review your medical history to ensure Estriol is safe and appropriate for you.
