• Customer Service Team available now: Mon-Fri 8:00-17:00
  • Private & confidential service
  • Genuine medication
  • All-inclusive service - No hidden fees
  • Next day delivery
  • HRT
  • Estriol Cream (Gynest)

Estriol Cream (Gynest)

Buy Estriol Cream after completing our online consultation for hrt

  • This tube contains 80g of Estriol 0.01% w/w with an applicator
1 tube (80g) (£48.99)

Prices include next-day delivery and prescription

1 tube (80g) £48.99
2 tubes (80g) £89.99 Save £8
3 tubes (80g) £124.99 Save £22

Select your treatment after the consultation:

Back to Start Consultation
Order today for FREE next-day delivery
Free next-day delivery
Lowest Price Promise: If you find it cheaper elsewhere, we refund the difference.
Price is all-inclusive

More information about Estriol Cream (Gynest)

What is Estriol cream?

Estriol cream is a type of topical hormone replacement therapy (HRT). It comes in the form of an intravaginal cream and is specifically used to treat vaginal problems in postmenopausal women.

At HealthExpress we offer the 0.01% strength of Estriol cream (Gynest), however if you regularly use the 0.1% strength (Ovestin) then you should speak to your doctor before purchasing.

How does Estriol cream work?

Menopause is the time period 12 months after a woman’s last period. It’s a natural part of ageing and occurs due to a hormonal imbalance. In particular, the ovaries begin to produce less of the hormone oestrogen (estrogen), otherwise known as one of the ‘female hormones’, which is what causes menopausal symptoms.

One of the many things that oestrogen is responsible for is the condition of the vaginal lining, ensuring it is elasticated and lubricated. This means as oestrogen levels drop during menopause, the vagina becomes drier. This vaginal dryness causes uncomfortable symptoms such as soreness, itching, pain during sex and needing to urinate more often. It also elevates the risk of recurrent vaginal infections such as urinary tract infections (UTIs), cystitis, thrush and bacterial vaginosis.

Estriol, sometimes spelt oestriol, targets these symptoms. Estriol is a steroid hormone and a weaker form of oestrogen. It works by supplementing the vaginal tissues with a form of oestrogen to improve elasticity and lubrication in the vagina.

What is the difference between Estriol and Estradiol?

Estriol and Estradiol are different bioidentical forms of oestrogens. Estradiol, whilst weaker than oestrogen, is a stronger form of hormone replacement than Estriol. This means it may be more effective for those who need a stronger dose of HRT. However, it may not be suitable for all women and Estriol is a great alternative for that reason.

Estradiol is an active ingredient of many HRT medications both on its own and combined with synthetic progesterone (norethisterone). It is available at HealthExpress in brands such as Elleste, Kliovance, Kliofem, Evorel Conti & Sequi, Femoston and Zumenon.

How do I use Estriol cream?

Estriol cream comes with a plastic applicator that you screw on to the tube. The initial dose of Estriol is one applicatorful applied daily for 3–4 weeks, then it can be reduced to 1 applicatorful twice weekly.

Estriol works best when it is applied at night time.

A comprehensive set of instructions including diagrams is available in the patient information leaflet.

A brief guide to administering Estriol cream is as follows:

  1. Remove the cap from the tube and use the top of the cap to pierce the foil seal on the tube.
  2. One end of the applicator has a plunger. Screw the other end of the applicator onto the tube.
  3. Squeeze the tube so that the applicator barrel is completely filled with the cream, this will push the plunger out.
  4. Unscrew the full applicator from the tube and replace the cap on it.
  5. To administer, lie down with your knees bent and spread apart.
  6. Gently insert the open end of the applicator well into your vagina.
  7. Push the plunger firmly but gently. Empty the cream into your vagina by pushing the plunger as far as it will go.
  8. Keep the plunger firmly pressed down as you grip the applicator barrel and remove it.
  9. Wash your hands and use a sanitary towel to stop your clothes getting stained.

It’s important you clean the applicator thoroughly after each use. Each time, pull the plunger out of the applicator barrel and clean with mild soap and warm water (not boiling). Rinse the soap off thoroughly.

If you forget a dose, take the missed dose as soon as you remember. Do not take two doses of Estriol in a day. If you take more Estriol than you should, seek immediate medical attention even if you feel fine.

What are the side effects of Estriol cream?

As with most prescription medicines, Estriol cream can cause some side effects.

Common side effects of Estriol include:

  • break-through bleeding (spotting)
  • vaginal discharge
  • needing to pass urine more often
  • pain whilst urinating
  • breast tenderness
  • feeling or being sick
  • headache
  • depression
  • fast or irregular heartbeat (palpitations)
  • skin reaction (e.g bruising or swelling)
  • stomach bloating or pain

If you experience any more severe adverse effects or think you’re having an allergic reaction, stop taking Estriol and speak to your doctor as soon as possible.

For a comprehensive list of side effects, please refer to the patient information leaflet which is available online or in the box with your medication.

Who can use Estriol cream?

Estriol is available for menopausal women who have vaginal atrophy symptoms. However, having certain pre-existing conditions may mean Estriol is not suitable for you.

You should not take Estriol if you have or have had:

  • an allergy to peanuts or soy
  • an allergic reaction to any of the listed ingredients
  • breast cancer or an elevated risk of breast cancer
  • a type of cancer that is exacerbated by oestrogens (e.g endometrial cancer)
  • blood clots (deep vein thrombosis) or have been told you are more at risk
  • blocked arteries that resulted in angina (chest pain) or a heart attack
  • porphyria (a blood condition)
  • abnormal vaginal bleeding that has not been diagnosed
  • untreated endometrial hyperplasia (thickening of womb lining)
  • liver disease

You should also not use Estriol cream if you are pregnant, breastfeeding or think you may be pregnant.

Your doctor may also want to monitor you if you have any long-term conditions such as asthma, epilepsy, diabetes, fibroids, endometriosis or high blood pressure.

If you are not sure if any of these contraindications apply to you, you should speak to your doctor before purchasing Estriol.

What precautions do I need to take whilst using Estriol cream?

Estriol cream contains arachis oil which is peanut oil. Therefore, you should not use Estriol cream if you have a peanut or soy allergy. The cream also contains benzoic acid, which can irritate your skin, eyes and nostrils if it comes into contact with it.

Because Estriol is a vaginal cream, it could interfere with your barrier contraception. If you use male or female condoms, you should check with your doctor if Estriol cream is suitable for you.

Estriol may also interact with other medications you take, including prescription, over-the-counter, herbal and recreational drugs.

You should be particularly cautious if you take:

  • medicines for epilepsy (e.g phenobarbital, phenytoin, lamotrigine or carbamazepine)
  • certain antibiotics (e.g rifampicin or rifabutin)
  • medicines for HIV (e.g ritonavir, nelfinavir, efavirenz or nevirapine)
  • bosentan - used for high blood pressure in the lungs
  • St John’s Wort - herbal medicine for depression

If you’re not sure what medication you take, speak to your doctor or pharmacist.

Can Estriol cream cause blood clots?

With some HRT treatments, there is a slight increased risk of blood clots such as deep vein thrombosis (DVT). This is a condition where a blood clot occurs in one of the deep veins in the leg and has the potential to dislodge and travel to the lung, where it can form a fatal blockage known as a pulmonary embolism.

It’s important to remember that this research demonstrates an association, and doesn’t mean all women taking HRT will develop a blood clot. In addition, the risk is incredibly low, especially for oestrogen-only HRT treatments and for HRT that is absorbed into the skin (patches, gels and creams).

If you’re worried about blood clots, you should consult with your doctor.

Can Estriol cream cause cancer?

Taking Estriol does increase your risk of developing gynaecological and urogenital cancers including breast cancer, ovarian cancer and endometrial cancer (uterine cancer). However, the risk is low for all types of HRT but it is particularly low for oestrogen-only treatments like Estriol. In fact, you are still at a much greater risk of these types of cancer if you have a high BMI or smoke.

Whilst the risk is low, it’s still important to consider what treatment is best for you and work closely with your doctor. You should also check regularly for any abnormal symptoms. It could be nothing, but it also could reduce your risk of any fatal conditions.

How do I buy Estriol cream online?

You can buy Estriol 0.01% (Gynest) cream online here at HealthExpress for the treatment of vaginal symptoms of menopause. All you have to do is fill out our quick, confidential medical questionnaire that will be reviewed by one of our UK registered doctors. Once they have approved you for treatment, the medication will be sent right to your door the next day.

Estriol Cream (Gynest) info
Product nameEstriol Cream (Gynest)
Active ingredient(s)Estriol
ManufacturerPHARBIL Waltrop GmbH
Lowest price£48.99
Trustpilot rating4.7/5
Trustpilot reviews24261
AvailabilityIn stock
DescriptionVaginal HRT cream to treat vaginal atrophy as a result of menopause
ExemptionSubject to medical prescription
Available dosageOne applicatorful each night
ApplicationWomen going through menopause
Posology Consult patient leaflet
Drug classEstrogen
Alcohol consumption No known interaction
When pregnant/breastfeedingNot recommended, speak to your doctor

Note: Decisions about treatment are for both the prescriber and the person to jointly consider during the consultation. However, the final decision will always be the prescriber’s.

Fill out a short
medical form
Doctor issues
Medication sent
from pharmacy
Service reviews
This tube contains 80g of Estriol 0.01% w/w with an applicator Excellent 4.7 24261 patients have reviewed our service on Trustpilot
24 May

Great fast service

Kevin K
24 May

Great service, arrived when they said it would.

24 May

All good. Easy to order and super fast delivery.

Catherine W
Select your Treatment

Further reading

Top 10 foods high in oestrogen

Top 10 foods high in oestrogen

Reviewed by Dr. Caroline Fontana
A guide to menopause symptoms: what every woman should know

A guide to menopause symptoms: what every woman should know

Reviewed by Dr. Plauto Filho
What are the different types of HRT?

Find your options for HRTs to help ease symptoms of menop...

Reviewed by Dr. Anand Abbot
Our patients love:
  • Helpful and friendly customer serviceWe’re available Mon - Fri, 08:00 - 17:00
  • No hidden feesAll prices include shipping & prescription
  • Next-day deliveryFor all orders before 16:30