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Semaglutide Tablets (Rybelsus)

Buy Rybelsus Semaglutide tablets for effective weight loss treatment

Prices of Tablets
30 pills
1 month (3mg starting dose) (£129.99)

Prices include next-day delivery and prescription

1 month (3mg starting dose) £129.99
1 month (7mg) £139.99
1 month (14mg) £149.99

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More information about Semaglutide Tablets (Rybelsus)

What is Rybelsus?

Rybelsus is a treatment that can be used for weight loss. It contains the same ingredient as Ozempic, Semaglutide, and works by reducing your appetite. Unlike the Semaglutide injections however, it is available in the form of tablets that you take just once per day.

It is suitable for those with a body mass index (BMI) of 30 and over and must be taken alongside a healthy diet and exercise regime to see the full benefits.

Rybelsus is licensed as a treatment for type 2 diabetes as it helps control blood sugar levels. However, clinical trials have found that one of the main benefits of taking it is weight loss, so it is often prescribed off-label for that reason. If you’re looking for Semaglutide for diabetes treatment, please visit our Ozempic page.

Please note: Rybelsus for weight loss is currently prescribed off-label.

How does Rybelsus work?

Rybelsus helps you lose weight by slowing down your digestion. This leaves you feeling fuller for longer and makes you feel less hungry. Over time, and with a healthy diet and exercise regime, this will reduce your body weight.

The active ingredient of Rybelsus is Semaglutide. It is the exact same active ingredient that is in Ozempic and belongs to the same family of drugs as Saxenda.

Semaglutide tablets work by targeting a specific hormone called GLP-1 (glucagon-like-peptide-1). GLP-1 is a naturally occurring hormone in the body which is responsible for blood sugar management and appetite. Semaglutide is a GLP-1 analogue which means it increases the levels of GLP-1 in the body. By doing so, it helps with blood sugar management in two main ways:

  • facilitates the production of insulin from the pancreas when your blood sugar levels are too high
  • reduces excess glucose (sugar) from the liver when it is not needed

This sequence of events means your stomach empties and digests food more slowly after eating. It is also the main mechanism that reduces blood glucose levels in those with type 2 diabetes.

What are the benefits of taking Rybelsus?

There are several benefits to taking Rybelsus to lose weight.

It’s effective

The main benefit is that the drug is effective. Multiple clinical studies have found patients on Rybelsus for type 2 diabetes lose as much as 4.5kg, up to 10% of their body weight, after around 52 weeks of treatment. Patients also saw significant reductions in waist size and other measurements.

It’s easy to take

It also has a unique benefit compared to other weight loss drugs in that it is easier to take. Most of the current weight loss drugs, whilst equally effective, require you to inject yourself daily or weekly. Rybelsus, however, is an oral medication. It’s a tablet that you can take just once a day - a perfect alternative for those anxious about needles.

It’s recommended by professionals

Whilst currently only available off-label for weight loss, in February 2022 NICE (National Institute for Health and Care Excellence) in the UK recommended Semaglutide for obesity treatment.

What dosages of Rybelsus are available?

Rybelsus tablets are available in 3 doses: 3mg, 7mg and 14mg. Your dose is increased gradually to promote sustainable and healthy weight loss.

For weight loss, you must start on the 3mg dose. Only once you are stable on that dose for one month can you progress to the 7mg dose. You may stay on the 7mg dose, but if deemed suitable by your doctor, your dose can be increased to 14mg after at least one month of being stable on the 7mg dose.

Do not alter your dose unless you have been instructed to do so by your doctor or healthcare provider.

You cannot exceed a dose of 14mg per day. If you take more than you think you should, consult your doctor as soon as possible.

How do I take Rybelsus?

Take one Rybelsus tablet once daily on an empty stomach.

You can take the tablet at any time of the day, but you must take it at least 30 minutes before your first meal or drink of the day. For most, this is first thing in the morning. Eating immediately after taking Rybelsus will reduce its efficacy.

Take tablets with a sip of water, no more than half a glass (around 120ml). Do not crush, split or chew tablets as this will reduce the absorption of the drug.

If you miss a dose, skip this dose and take your normal dose the next day. Do not stop taking Rybelsus unless you have been instructed to do so by your doctor or healthcare provider.

If after 12 weeks on the maximum dose you have not lost at least 5% of your initial body weight, treatment should be discontinued and you should consult your doctor for an alternative.

What are the possible side effects?

Like all prescription medicines, Rybelsus can cause some side effects. However, the most common are mild and go away on their own.

Common side effects include:

  • nausea (feeling sick)
  • vomiting (being sick)
  • indigestion and general stomach discomfort
  • acid reflux and heartburn
  • bloating and gas (flatulence)
  • constipation
  • inflammation of the stomach (gastritis)

Those who also take certain other diabetes medicines such as Metformin, are at a higher risk of experiencing low blood sugar (hypoglycaemia or hypo) whilst using Rybelsus. It’s important you treat it straight away once you notice the symptoms.

Warning signs for low blood sugar include:

  • cold sweat and cool pale skin
  • headache
  • increased heart rate
  • nausea
  • feeling very sleepy or weak
  • feeling hungry
  • feeling nervous, anxious or confused
  • difficulty concentrating
  • shaking
  • vision changes

For a full list of the potential side effects, including more serious side effects, please refer to the patient information leaflet. It will be in the box with your medication but is also available to download from this page.

Who can take Rybelsus?

You can take Rybelsus for weight loss if you have a body mass index (BMI) of 30 and above, or 27 and above if you have a weight-related condition such as high blood pressure, high cholesterol or type 2 diabetes.

You must not take Rybelsus if you:

  • are pregnant, think you may be pregnant or are breastfeeding
  • are under the age of 18
  • are allergic to any of the ingredients
  • have type 1 diabetes
  • have diabetic ketoacidosis (complication of diabetes where your blood sugar is very high)

If you have any other long-term conditions or take any medications, you should always consult your doctor before taking Rybelsus so they can ensure it’s safe for you to take.

You should especially tell your prescriber if you:

  • have eye problems caused by diabetes (diabetic retinopathy)
  • have kidney or heart problems
  • have a history of pancreatitis
  • take insulin
  • take levothyroxine for thyroid disease
  • take medicines to reduce blood clotting (e.g warfarin)

This is because Rybelsus has been known to affect these conditions or interact with these medicines, so your doctor will want to monitor you whilst on this medication.

If you’re not sure whether you fall under any of these groups, check with your doctor or healthcare provider before taking Rybelsus.

How do I buy Rybelsus online?

Rybelsus 3mg, 7mg and 14mg tablets are available to purchase off-label for weight loss treatment here at HealthExpress. All you have to do is complete a short online medical questionnaire which will then be reviewed by one of our UK-registered doctors. Once they have approved you for treatment, our in-house pharmacy will dispense and dispatch your treatment with free next-day delivery.

Semaglutide Tablets (Rybelsus) info
Product nameRybelsus
Active ingredient(s)Semaglutide
ManufacturerNovo Nordisk
Lowest price£129.99
Trustpilot rating1/5
Trustpilot reviews1
AvailabilityIn stock
DescriptionA diabetes treatment prescribed off-label for weight loss
ExemptionSubject to medical prescription
Available dosage(s)One 3mg, 7mg or 14mg tablet to be taken once per daily.
ApplicationAdults over 18 with a of BMI over 30 (or over 27 and have weight-related conditions)
PosologyConsult patient leaflet
Drug classGlucagon-like-peptide-1 (GLP-1) receptor agonists
Alcohol consumptionIn moderation
Breastfeeding/pregnancyNot recommended

Note: Decisions about treatment are for both the prescriber and the person to jointly consider during the consultation. However, the final decision will always be the prescriber’s.

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