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Combined Pill

Information and advice on the combined contraceptive pill

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Dr Hilary Jones discusses the combined contraceptive pill and the treatments available at HealthExpress

In the UK alone a over 3.5 million women use the combined pill making it the most popular type of contraception around, and with very good reason. Not only is it over 99% effective at preventing pregnancy but there are a whole host of secondary benefits it provides. More commonly known as 'the pill', it contains both synthetic versions of the female hormones oestrogen and progestogen, and can also be used to treat heavy periods, premenstrual syndrome and endometriosis.

If you are already using a combined pill method and know what you require, you can select from the list below and order today after taking our quick online consultation. If you would however like more information regarding combined pill methods please see further below.

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Available treatments

Yasmin  Bayer
  • Almost 100% effective at preventing pregnancy
  • Contains both artificial progestogen and oestrogen hormones
  • Reduced risk of side effects – such as weight gain
  • Free same day and next day delivery service
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  • Simply fill out our brief consultation in less than 3 minutes.
  • A doctor will review your details within minutes and recommend a treatment(s).
  • You can order your treatment which will be dispatched within 24h.

What is the combined pill?

The combined pill is an oral tablet used by millions of women to prevent pregnancy, of which it is 99% effective in doing so. Most commonly referred to as 'the pill', many women also take the pill to help soften period cramps, regulate menstrual cycle and sometimes help to control acne.

The combined contraceptive pill differs from the mini pill (also known as the POP pill or protegestogen only pill) in not only how it is taken, but with the ingredients and dosages; the pill contains both oestrogen and progestogen, whilst the mini pill only contains the latter, and it is taken for 21 days with a 7-day break. There is no difference in effectiveness, however most women will be offered the combined pill option as it is highly tolerable, easy to take and easily obtainable making it a highly demanded method of contraception.

There are many combined pill brands with Cilest, Microgynon and Yasmin being the three main choices. They are all very similar to each other, however you may find some combined pills will be more appropriate than others for you depending on factors including whether you smoke, experience migraines, or your age. Due to the wide variety of options available you are bound to find a pill that is suited to your needs. Although there may be some trial and error an online consultation here or a visit to your GP can help you identify which combined pill works best for you.

Combined pill brands available in the UK

*Available here online at HealthExpress

How does the combined pill work?

This contraceptive method can be taken at any point once prescribed. If taken on the first to fifth day of your period, it will be immediately effective. If it is taken outside this timeframe,then an additional barrier option will be required for the first week or two before being fully protected. Technically speaking, the pill works in three ways:

  • It stops the ovaries from releasing eggs, therefore stopping ovulation
  • It also thickens the vaginal fluid to prevent sperm from reaching the womb
  • Lastly, it makes the womb walls thinner, so if an egg were to be released, it would be unable to attach itself to the womb

It will only be 99% effective if taken correctly detailed under our 'How to take the pill' section.

*Please note that the combined pill cannot protect you against sexually transmitted infections. Please use barrier contraceptives such as condoms if you are concerned about your sexual health.

Benefits of using the combined pill?

The combined contraceptives are over 99% effective at preventing pregnancy and this is their main benefit and why they were made, however you can also take the pill if you wish to control acne outbreaks, help ease menstrual cramps or alleviate the symptoms of endometriosis. These additional pluses can be used in conjunction with preventing pregnancy as well, or on their own. Other benefits to using this pill include:

  • Ease of use and discretion

    Many women take their birth control first thing in the morning or last thing at night as part of their daily routine.

  • Lighter and more regular periods

    This will ease the symptoms associated with your menstrual cycle such as cramps, pains and heavy flow.

  • Heavy and long period reduction

    Hormonal contraception can make periods shorter and lighter.

  • Treat PCOS

    Polycystic ovary syndrome can affect the hormones causing painful periods, excess facial hair and weight gain. Hormonal contraceptives can help to control many associated symptoms.

*The pill may not be appropriate if you have had cancer previously. For more information regarding the pill if you have had cancer, check out the NHS resources[1].

Using the combined pill

With oral combined contraceptives, one pill must be taken at the same time daily for 21 days of the month, followed by a 7-day break. During this break you will experience breakthrough bleeding. Even in this week off, you will still be fully protected against conception.

After the 7-day break you should begin your next pill pack following the same rules and continue this cycle until you don't wish to used a hormonal contraceptive method any longer.

There are a couple of combined pill brands including Zoely and Qlaira that differ from the usual 21-day method. These brands contain 28 pills. This is a good option for those who are particularly forgetful, especially when remembering to start a new pack on the correct day.

No period after coming off the pill

It is common to not experience a withdrawal bleed in the 7-day break and doesn't categorically mean you are pregnant. If you have taken the pill correctly (around the same time without being sick or missing any) then the likelihood of pregnancy is extremely low. It is advised to carry on with your next pill pack, then if you don't experience a bleed the following month, to seek medical advice with your GP.

Bleeding between periods on the pill

Bleeding whilst taking the pill is also a fairly common occurrence, especially when you're first taking the medication. Also referred to as a 'breakthrough bleed' or 'spotting', this is particularly typical when starting the pill as your body begins to adjust to the new hormones. Continue taking the pill as detailed and seek further information if you have experienced withdrawal bleeding for over 3 months.

What if I miss a pill?

Forgetting to take a pill is a common scenario to be in so here's a simple checklist of what you need to do if you miss a pill. This will depend on how many, when and where you are in your cycle:

You have missed one pill or have started the new pack one day late

  • Take your pill as soon as you remember, even if this means taking two pills in one day
  • Continue your pack as normal
  • You will still be protected and won't require any additional protection against pregnancy

You have missed two or more pills or have started the new pack two or more days late

  • Take the last missed pill as soon as possible, even if this means taking two pills at the same day
  • Leave the other missed pill(s) and continue to take one pill daily as normal
  • During this time you will NOT be protected against pregnancy. Seek additional barrier methods of contraception or avoid sexual intercourse until you have started your next pack after the 7-day break

If there are six or less pills left in the pack

  • Finish the pack as normal
  • Start the new pack the next day without the 7-day break
  • During this time you will NOT be protected against pregnancy. Seek additional barrier methods of contraception or avoid sexual intercourse until you have started your next pack after the seven-day break

If there are seven or more pills left in the pack

  • Finish the pack as normal
  • Take your 7-day 'pill break' as normal, before starting the next pack
  • During this time you will NOT be protected against pregnancy. Seek additional barrier methods of contraception or avoid sexual intercourse until you have started your next pack after the seven-day break

If you don't use further protection, you will need to consider emergency contraception.

What if I vomit or experience diarrhoea while taking the pill?

Falling ill with the common cold or other related illnesses will not have an effect on the efficiency of your birth control unless you experience vomiting or diarrhoea. If you vomit or have been experiencing severe diarrhoea within 3 hours of taking your pill, it could mean that it hasn't been fully absorbed into your bloodstream.

Continue as usual when the vomiting or diarrhoea subsides, if more than one pill is missed during this period then you may need to use a barrier contraceptive such as a condom for the next week before you are fully protected again.

What are the side effects of the combined pill?

Like any form of prescription medication, the combined contraceptive pill contains a risk of side effects; these are usually mild and temporary. These will generally be experienced within the first three months of going on the pill, as your body is becoming accustomed to the medication.

Common and uncommon side effects

The combined contraceptive pill is well tolerated for the vast majority of women, however there are some common and uncommon side effects to be aware of when considering it as a method of contraception. Below are the side effects as listed by the US National Library of Medicine:

Common side effects Uncommon side effects
  • Nausea or vomiting
  • Headaches
  • Stomach cramps or bloating
  • Diarrhoea or constipation
  • Increase or decrease in appetite
  • Weight gain or weight loss
  • Bleeding or spotting mid cycle
  • Heavier or lighter menstrual flow
  • Breast tenderness, enlargement or discharge
  • Vaginal discharge
  • Dark patches on skin
  • Mood changes
  • Severe vomiting
  • Relationship issues
  • Faintness or dizziness
  • Weakness or numbness in limbs
  • Chest pain or heaviness
  • Shortness of breath
  • Coughing up blood
  • Vision loss or blurring
  • Yellowing of skin or eyes (jaundice)
  • Loss of appetite
  • Dark coloured urine
  • Fever or rash
  • Depression or insomnia
  • Heavy or prolonged bleeding for more than 7 days

When considering the term "common" with medication, this can be somewhat misleading as only a minority of women taking the combined pill will experience these side effects, and these tend to be temporary and mild in nature during the first few months of starting the medication.

Doctors will advise you to continue taking that particular combined contraceptive for up to three months by which point these side effects should have subsided considerably or disappeared altogether.

Rare side effects

There are some rare but potentially dangerous side effects associated with taking the combined pill.

The pill and blood clots

The oestrogen in the pill can make your blood clot more willingly. If blood clots do form, you could develop clots in your legs (a condition known as deep vein thrombosis) or a clot in your lungs (a condition known as a pulmonary embolism). These conditions can lead to stroke or heart attack.

A large scale study of two GP Databases in the UK was published in the British Medical Journal in 2015. It analysed the incidence of blood clots amongst those taking oral contraceptives across 1,340 GP Practices. It found that while the pill did increase the risk of blood clots threefold over baseline, it was still considered a rare side effect, with the increase being six in 10,000 blood clots in women taking the pill.

The pill and cancer

There is ongoing research into a link between taking the combined pill and a slightly higher chance of developing breast cancer, cervical cancer and a rare liver cancer, however this is an extremely minimal amount. In fact, according to the NHS, the pill can offer you some protection against developing other cancers such as ovarian cancer, colon cancer and endometrium cancer.

Cancer Research UK reported how short-term use seems to have little effect, but if taking the combined pill for five years or longer, you can double your risk of developing cervical cancer compared to women who don't take the pill. This risk falls again once you stop taking the pill and after ten years, the additional risk has disappeared. Similarly, with your increase risk of breast cancer, after ten years of stopping the pill the increased risk vanishes.

Dealing with combined pill side effects

The most common side effects of taking the combined pill are headaches, mood swings, nausea and breast tenderness. These are usually temporary and will disappear within the first few months of use. Breakthrough bleeding is also common in the first few months. If any of these symptoms persist you should speak to your doctor, as another pill or brand may be more suitable for you.

If you notice any symptoms of the rare or more serious side effects, you should seek medical advice immediately. You should also speak to your doctor if your circumstances or health change and you now fall into one of the risk categories above. For example, if you develop high blood pressure or if you start smoking, you may need to stop taking the combined pill.

What precautions to take with the combined pill

The combined pill may not suitable if you:

You should always disclose any medical history or medications you take to your doctor before starting a new form of contraception. This includes in our consultation process.

Antibiotics and the pill

If you are currently taking other medication or antibiotics, including herbal medications, this could affect the combined pill's effectiveness. It is therefore advised that you speak to your doctor about any other medications you are taking.[2]

If you have any of these health complications or conditions, there is no need to fret; you still may be able to use the combined pill and other contraception options are available too. You can be prescribed an alternative such as the mini pill.

Myths surrounding the combined pill

The pill and weight gain – If you have experienced weight gain, it is mostly likely down to fluid retention due to the level of synthetic hormones. This is very often temporary especially when taking new medication. Not only is there an extremely slim chance of significant and noticeable weight gain, but newer versions of the pills contain even less oestrogen making weight gain even less likely.

The combined pill increases the chance of cancer – On the contrary. Studies have shown that the risk of ovarian and endometrial cancer are reduced when taking the pill. The only increased risk is linked to breast cancer and cervical cancer, and even this is very slim. Cancer Research UK has further information on the combined pills link to developing cancer. [3]


Combined pill and migraines – Whilst reports have shown that a small minority of women find their migraines and headaches become even more severe whilst taking the pill, this is not the case with the majority. In fact, some have found that they improve and you still might be able to take the combined pill. The easiest way to clarify is to seek medical advice from your GP before starting a new pill.

Can you get pregnant on the pill – Yes. Getting pregnant on the pill is a possibility if you haven't taken it correctly. For example, if you missed a couple in your pack, the effectiveness drops. For more advice on what to do, check out our 'Missed Pill' section and whenever in doubt, use further barrier contraceptive methods or consider the morning after pill.

How can I buy the combined pill online safely?

The combined contraceptive pill is available to purchase online in the UK at HealthExpress after you complete an online consultation form, which you can do by clicking on the button below. This takes a couple of minutes and once completed a doctor will assess your suitability to the medication and will help you to find an alternative should your first choice be unsuitable. Once successful, a prescription will be issued and your package will be delivered straight from our pharmacy for free delivery. As you regularly need contraception – usually every 3 months – obtaining yours online is becoming an increasingly popular method.

  • No waiting around for appointments and prescriptions
  • 14 contraceptive options available
  • It's all done in the comfort of your own home
  • Free next day delivery on orders before 4pm
  • Free same day delivery to London postcodes on orders before 4pm
  • Fully registered by GMC UK, National Pharmacy Association and CareQuality Commission

Registered Pharmacy


Dr Hilary Jones, HealthExpress Medical Advisor

How can prescription Hormonal contraception treatment help me?

Hormonal contraception is one of the most common methods used by women to prevent pregnancy. With the large number of options available, it has become much easier to find the method that suits your body and lifestyle best. Some of the options we provide are; Yasmin, Dianette and Cilest, all of which are approved by UK registered doctors and are clinically proven to effectively prevent pregnancy. These medications can be safely and discreetly obtained after completing our simple online consultation.

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